Download sun and vitamin d7/15/2023 ![]() Of course, there were no precise medical details that distinguished it from other bone diseases, but treatises describing the symptoms and lithographs from that time showing bone deformities resembling rickets leave little doubt that it was vitamin D deficiency. It began in the early 1600s with the first descriptions of the human deficiency disease: rickets in children and osteomalacia in adults. ![]() ![]() The history of vitamin D is a rich and storied subject and is now over 350 years old. The overview is divided into four distinct historical phases which cover the major developments in the field and in the process highlighting the: (a) first recognition of rickets or vitamin D deficiency (b) discovery of the nutritional factor, vitamin D and its chemical structure (c) elucidation of vitamin D metabolites including the hormonal form, 1,25-dihydroxyvitamin D 3 (d) delineation of the vitamin D cellular machinery, functions and vitamin D-related diseases which focused on understanding the mechanism of action of vitamin D in its many target cells. This comprehensive historical review provides a unique perspective of the many steps of the discovery of vitamin D and its deficiency disease, rickets, stretching from 1650 until the present. ![]() ![]() It is believed that many of the hormonal effects of vitamin D involve a 1,25-dihydroxyvitamin D 3-vitamin D receptor-mediated transcriptional mechanism involving binding to the cellular chromatin and regulating hundreds of genes in many tissues. Vitamin D has many physiological functions including upregulation of intestinal calcium and phosphate absorption, mobilization of bone resorption, renal reabsorption of calcium as well as actions on a variety of pleiotropic functions. ![]()
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